Advancing Allergy Research

Intersecting Allergy and Genetics to ask

"How do we get allergies?"

so that we can learn how to stop it.

We use Mouse and Human Genetic Studies of IgE and Genetic Food Allergy to research this fundamental question.

UT Southwestern Medical Center

Department of Pathology

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Meet the Principal Investigator

Jeffrey SoRelle, M.D.

I am a physician, scientist, and entrepreneur, passionate about discovering the mechanisms of allergic diseases. I am excited to translate the discoveries into new treatments on diagnostic tests. Then, I am excited to translate these discoveries into new treatments on diagnostic tests.

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Our Work

Current Research

Genetic Studies

Conducting human genetic studies to identify mutations and genes associated with allergic diseases, aiming to develop innovative therapies and diagnostics to improve patient outcomes.

Molecular Mechanisms

Investigating the molecular mechanisms underlying allergies using mouse models discovered from a forward genetic approach.

Glycosylation and Gut Health

We have discovered glycosylation in gut mucus proteins help defend the gut. This could influence how food allergy or IBD is treated

IgE Glycosylation

We have found that certain sugars on IgE can change its function, stability and structure. We are leveraging this to create more diagnostic tests to diagnose Food Allergy Health.

The SoRelle Lab